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Characterization of the crosstalk between Notch signaling and hypoxia

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NIAID Data Ecosystem2026-03-13 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP355821
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资源简介:
The Notch signaling pathway regulates several differentiation and developmental processes. Reduction of oxygen availability, a condition referred to as hypoxia, impacts on the Notch response. Here we made use of RNA-Seq and ChIP-Seq analysis to investigate the Notch/hypoxia crosstalk at genomic level. Overall design: Mouse pre-T cells (Beko) were treated with the DMOG or kept under low oxygen concentration to induce hypoxia. Effects on gene expression were investigated by RNA-Seq and RBPJ occupancy was analyzed by ChIP-Seq.
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2022-07-21
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