proMMP9 binds TIMP1

ProMMP9 binds Tissue Inhibitor of Metalloproteinases 1 (TIMP1) (Wilheim et al. 1989). By homology with the binding of TIMP2 to the MMP2 hemopexin domain, TIMP1 is thought to binds via its C domain to the MMP9 hemopexin domain. This is a two-way potential regulatory mechanism as the interaction does not prevent the free N-terminal inhibitory domain of TIMP1 from inhibiting other MMPs (Murthpy et al. 1991) while it may prevent the activation of proMMP9.

ProMMP9与组织金属蛋白酶抑制剂1（TIMP1，Wilhelm等，1989年）结合。根据与TIMP2结合MMP2血红素结合域的同源性，推测TIMP1通过其C结合域与MMP9血红素结合域结合。这是一种双向潜在调节机制，因为这种相互作用并不妨碍TIMP1的游离N端抑制域抑制其他MMPs（Murthpy等，1991年），同时可能阻止前MMP9的激活。