Enantioselective Synthesis of 2‑Arylbicyclo[1.1.0]butane Carboxylates
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https://figshare.com/articles/dataset/Enantioselective_Synthesis_of_2_Arylbicyclo_1_1_0_butane_Carboxylates/2451226
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资源简介：
The rhodium-catalyzed reaction of 2-diazo-5-arylpent-4-enoates can be controlled by the appropriate choice of catalyst and catalyst loading to form either 2-arylbicyclo[1.1.0]butane carboxylates or cyclohexene derivatives. Both products are produced in a highly diastereoselective manner, with 2-arylbicyclo[1.1.0]butane carboxylates preferentially formed under low catalyst loadings. When the reaction is catalyzed by Rh2(R-BTPCP)4, the 2-arylbicyclo[1.1.0]butane carboxylates are generated with high levels of asymmetric induction (70–94% ee).
创建时间：
2016-02-20
