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Praseodymium(III)-Catalyzed Regioselective Synthesis of C3‑N-Substituted Coumarins with Coumarins and Azides

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Figshare2017-08-16 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Praseodymium_III_-Catalyzed_Regioselective_Synthesis_of_C_sub_3_sub_N-Substituted_Coumarins_with_Coumarins_and_Azides/5314720
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A series of C3-N-substituted coumarins were synthesized in good yields directly from coumarins and azides in the presence of Pr­(OTf)3 without any additives or ligands needed. The selected compounds 3a, 3c–e, 3g, 3i, 3q, 3u, and 3v exhibited good anticancer activities against MGC-803, A549, and NCI-H460 cell lines with IC50 in the range 8.75–38.54 μmol L–1.
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2017-08-16
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