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Epigenome profiling reveals significant DNA demethylation of interferon signature genes in lupus neutrophils

ChEBI2015-01-21 更新2026-07-21 收录

狼疮表观遗传学

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-65097 数据链接链接失效反馈

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Epigenome profiling reveals significant DNA demethylation of interferon signature genes in lupus neutrophils

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2015-01-21

细胞分化调控

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To analyze the effect of type I IFN on global gene expression in differentiating monocytes, we employed microarray-based gene expression profiling. The MACS-purified mouse BM monocytes were cultured i

NIAID Data Ecosystem90

Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome III

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唐氏综合症治疗

Individuals with Down syndrome have a increased likelihood of suffering from inflammatory and autoimmune conditions, due to the presence of four interferon receptors on chromosome 21. Transcription of

NIAID Data Ecosystem50

A Robust Induction of Type III Interferons and Chemokines Defines a Unique Pattern of Hepatic Innate Immunity in Response to Hepatitis C Virus Infection

丙型肝炎免疫机制

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Recent identification of IL28B gene polymorphisms associated with hepatitis C virus (HCV) clearance suggests a role for type III interferons (IFNs) in hepatitis C infection. The function of type III I

NIAID Data Ecosystem50

Epigenome profiling reveals significant DNA demethylation of interferon signature genes in lupus neutrophils

系统性红斑狼疮

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We identified genome-wide DNA methylation patterns within neutrophils and low-density granulocytes of Lupus patients and demographically matched controls Comparison of 15 Lupus patients vs 15 age-, se

NIAID Data Ecosystem70

High dose IFN-𝛽 activates GAF to enhance expression of ISGF3 target genes in epithelial cells

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基因表达调控

GAF is transcriptionally inactive in epithelial cells but enhances expression of ISGF3 target genes, thus functioning as a dose-sensitive amplifier of the IFN-𝛽 response. Sequencing data from MLE-12

NIAID Data Ecosystem50

Epigenome profiling reveals significant DNA demethylation of interferon signature genes in lupus neutrophils

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