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Metal-Free [2 + 2 + 2] Cycloaddition of Ynamide–Nitriles with Ynamides: A Highly Regio- and Chemoselective Synthesis of δ‑Carboline Derivatives

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Figshare2018-10-23 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Metal-Free_2_2_2_Cycloaddition_of_Ynamide_Nitriles_with_Ynamides_A_Highly_Regio-_and_Chemoselective_Synthesis_of_Carboline_Derivatives/7243232
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资源简介:
A metal-free formal [2 + 2 + 2] cycloaddition of functionalized ynamide–nitriles with ynamides is disclosed which offers highly efficient access to polysubstituted δ-carboline derivatives under the mediation of TfOH. This strategy is highly regioselective and chemoselective and displays mild conditions, high yields, and efficiency (within 1 min) in addition to substrates scopes (56 examples).
创建时间:
2018-10-23
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