Kirschner1998_Immunotherapy_Tumour

This a model from the article:
Modeling immunotherapy of the tumor-immune interaction.

Kirschner D, Panetta JC. J Math Biol
1998 Sep;37(3):235-52 9785481
,
Abstract:

A number of lines of evidence suggest that immunotherapy with the cytokine
interleukin-2 (IL-2) may boost the immune system to fight tumors. CD4+ T cells,
the cells that orchestrate the immune response, use these cytokines as signaling
mechanisms for immune-response stimulation as well as lymphocyte stimulation,
growth, and differentiation. Because tumor cells begin as 'self', the immune
system may not respond in an effective way to eradicate them. Adoptive cellular
immunotherapy can potentially restore or enhance these effects. We illustrate
through mathematical modeling the dynamics between tumor cells, immune-effector
cells, and IL-2. These efforts are able to explain both short tumor oscillations
in tumor sizes as well as long-term tumor relapse. We then explore the effects
of adoptive cellular immunotherapy on the model and describe under what
circumstances the tumor can be eliminated.
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
Kirschner D, Panetta JC. (1998) - version=1.0

The original CellML model was created by:
Catherine Lloyd

[e-mail]
The University of Auckland
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