We describe several new aromatic nitrogen mustards with various aromatic substituents and boronic esters that can be activated with H2O2 to efficiently cross-link DNA. In vitro studies demonstrated th

NIAID Data Ecosystem30

Phenylazo-pyridine and Phenylazo-pyrazole Chlorido Ruthenium(II) Arene Complexes: Arene Loss, Aquation, and Cancer Cell Cytotoxicity

抗癌药物研发

金属配合物细胞毒性

Ru(II) η6-arene complexes containing p-cymene (p-cym), tetrahydronaphthalene (thn), benzene (bz), or biphenyl (bip), as the arene, phenylazopyridine derivatives (C5H4NN:NC6H5R; R = H (azpy), OH (azpy-

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Water Mediated Synthesis and Anticancer Evaluation of Oxindole-embedded Chalcone Hybrids: Insights from Computational Studies and A549 Cell Line Assay

抗癌药物研发

药物设计

This study presents a novel water-mediated synthesis method for oxindole functionalized chalcone derivatives, which have various therapeutic applications, particularly in cancer treatment. The newly s

Figshare2025-03-09 更新40

Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting‑1 (Pin1)

抗癌药物研发

共价抑制剂设计

The unique proline isomerase peptidyl-prolyl isomerase NIMA-interacting-1 (Pin1) is reported to activate numerous cancer-driving pathways simultaneously, and aberrant Pin1 activation is present in man

NIAID Data Ecosystem30