Brugia malayi Raw sequence reads

In this study, we profiled the transcriptomes of Brugia malayi and the endosymbiotic bacteria, Wolbachia, over the lifecycle of the parasite. This allowed us to identify the functional pathways involved in this essential symbiotic relationship provided by the co-expression of nematode and bacterial genes. We have identified significant stage-specific differential expression in both Wolbachia and B. malayi during development of the worm. This concurrent transcriptional analysis has highlighted the co-expression of pathways between Wolbachia and B. malayi over the lifecycle of the parasite and paves the way for the development of novel intervention strategies.