Repeated exposure to lidocaine induces hippocampal synaptic and cognitive impairment in aged mice by activating microglia and neurotoxic A1astrocytes

To investigate changes in hippocampal genes mice after lidocaine injections Young and old mice were randomly divided into control groups and lidocaine groups. Multiple injections of lidocaine were administered to both young and old mice, followed by RNA sequencing of the hippocampus to observe the effects of lidocaine on hippocampal gene expression