Performance evaluation in pairwise comparison tests using four methods (ANOVA, LIMMA, KW and Proposed) for the small-sample case.

We generated 300 DE genes out of 20,000 total genes for m = 4 conditions with different patterns for a small-sample case (n1 = n2 = n3 = n4 = 6) and σ2 = 0.05, with a 2-fold change in expression between the groups, to investigate the pattern-detection performance of the proposed method in comparison with the others. The values reported in the form {x, x, x, x} in this table represent the numbers of downregulated (DR) or upregulated (UR) differentially expressed (DE) genes estimated by the ANOVA, LIMMA, KW and proposed (Bold) methods, respectively. aNote that logμ^iμ^j−1 indicates significant 2-fold downregulation and logμ^iμ^j>+1 indicates significant 2-fold upregulation.Performance evaluation in pairwise comparison tests using four methods (ANOVA, LIMMA, KW and Proposed) for the small-sample case.