Crystal Structure of Human IDH1 R132Q in complex with NADPH and Alpha-Ketoglutarate

Crystal Structure of Human IDH1 R132Q in complex with NADPH and Alpha-Ketoglutarate Descriptor: (3~{S})-3-[(4~{S})-3-aminocarbonyl-1-[(2~{R},3~{R},4~{S},5~{R})-5-[[[[(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-3,4-bis(oxidanyl)oxolan-2-yl]-4~{H}-pyridin-4-yl]-2-oxidanylidene-pentanedioic acid, 2-OXOGLUTARIC ACID, CALCIUM ION, ... Authors: Mealka, M, Sohl, C.D, Huxford, T. Deposit date: 2023-12-31 Release date: 2024-04-24 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms. Nat Commun, 15, 2024人源异柠檬酸脱氢酶1（Isocitrate Dehydrogenase 1, IDH1）R132Q突变体与还原型烟酰胺腺嘌呤二核苷酸磷酸（Nicotinamide Adenine Dinucleotide Phosphate, NADPH）及α-酮戊二酸结合的晶体结构 描述：(3S)-3-[(4S)-3-氨基甲酰基-1-[(2R,3R,4S,5R)-5-[[[[(2R,3R,4R,5R)-5-(6-氨基嘌呤-9-基)-3-羟基-4-膦酰氧基四氢呋喃-2-基]甲氧基-羟基膦酰基]氧基-羟基膦酰基]氧甲基]-3,4-二羟基四氢呋喃-2-基]-4H-吡啶-4-基]-2-氧代戊二酸、2-氧代戊二酸、钙离子…… 作者：Mealka, M、Sohl, C.D、Huxford, T. 提交日期：2023-12-31 发布日期：2024-04-24 最后修改日期：2024-05-22 解析方法：X射线衍射（2.28 Å） 引用：肿瘤相关IDH1突变体的活性位点重塑驱动差异化动力学特征及潜在耐药机制，《自然·通讯》（Nat Commun），2024年，第15卷