In-vitro penetration parameters of 5-FU in porcine and human tissue.

L is lag time; Jss is flux at steady state; Q48 is cumulative amount of drug permeated per cm2 of the tissue at 48 hrs; CT is tissue drug amount at 48 hrs. Results are presented as mean ± SEM (n = 3–4); ‘a’ is significant in comparison to porcine skin; ‘b’ is significant in comparison to human nipple with keratin plug; ‘c’ is significant in comparison to human skin. The values are significant at pIn-vitro penetration parameters of 5-FU in porcine and human tissue.