mRNA Expression data from murine hearts subjected to ligation of the left anterior descending coronary artery (myocardial infarction, MI model) or sham surgery (SH)

The left anterior descending coronary artery permanent ligation model of myocardial infarction was used to study the time of day differences in genetic responses post-MI between sleep-time MI, wake-time MI, wake-sham and sleep-sham mouse hearts. The micorarray approach allows the investigation of gene expression changes of all genes in sleep-time MI vs. wake-time MI vs. sham hearts. There are a total of 12 samples, 6 from cardiovascular disease MI and 6 from normal SHAM hearts collected 8 hours after surgery. Specifically for MI: There were 3 mice sacrificed 8 hours after wake-time MI as biological replicates, and there were 3 mice sacrificed 8 hours after sleep-time MI as biological replicates. Specifically for SHAM: There were 3 mice sacrificed 8 hours after wake-time SH as biological replicates, and there were 3 mice sacrificed 8 hours after sleep-time SH as biological replicates.