CPPA: A Web Tool for Exploring Proteomic and Phosphoproteomic Data in Cancer

A tremendous amount
of proteomic and phosphoproteomic data has
been produced over the years with the development of mass spectrometry
techniques, providing us with new opportunities to explore and understand
the proteome and phosphoproteome as well as the function of proteins
and protein phosphorylation sites. However, a lack of powerful tools
that we can utilize to explore these valuable data limits our understanding
of the proteome and phosphoproteome, particularly in diseases such
as cancer. To address these unmet needs, we established CPPA (Cancer
Proteome and Phosphoproteome Atlas), a web tool to mine abnormalities
of the proteome and phosphoproteome in cancer based on published data
sets. All analysis results are presented in CPPA with a flexible web
interface to provide key customization utilities, including general
analysis, differential expression profiling, statistical analysis
of protein phosphorylation sites, correlation analysis, similarity
analysis, survival analysis, pathological stage analysis, etc. CPPA
greatly facilitates the process of data mining and therapeutic target
discovery by providing a comprehensive analysis of proteomic and phosphoproteomic
data in normal and tumor tissues with a simple click, which helps
to unlock the precious value of mass spectrometry data by bridging
the gap between raw data and experimental biologists. CPPA is currently
available at https://cppa.site/cppa.