Epithelial dysfunction is prevented by IL-22 treatment in a Citrobacter rodentium-induced colitis model that shares similarities with Inflammatory Bowel Disease

We unveiled the disease relevance of the C. rodentium induced colitis model to IBD and demonstrated the protective role of the mucosal healing therapy IL-22.Fc in ameliorating the epithelial dysfunction Overall design: 10x scRNA-seq of Citrobacter rodentium infected FVB mice with or without treatment with IL22.Fc, as well as naïve non-infected FVB mice as controls The HTO data has not been used for any analysis and is not included.