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Enhancement of suppressive function of Ly49+ CD8+ T cells in allogeneic immunity by CD80/86-CD28 blockade

NIAID Data Ecosystem2026-05-10 收录

器官移植免疫排斥

CD28共刺激阻断

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https://www.ncbi.nlm.nih.gov/sra/ERP184452 数据链接链接失效反馈

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We performed RNA sequencing on grafts after heart transplantation under three conditions: syngeneic, allogeneic, and allogeneic with anti-CD80/86 antibody treatment.

应用场景：

创建时间：

2026-01-01

器官移植免疫排斥

单细胞转录组学

Renal transplantation is currently the most effective treatment for end-stage renal disease. However, chronic antibody-mediated rejection (cABMR) remains a serious obstacle for the long-term survival

NIAID Data Ecosystem30

T cell receptor repertoire profiling of murine skin transplantation in context of PD-1+ cells Ablation therapy

T细胞受体库

器官移植免疫排斥

The purpose of this study was to evaluate the influence of ablating PD-1+ cells on alloreactive T cell repertoires. We established the murine skin transplantation model and obtained the draining lymph

NIAID Data Ecosystem20

Gene expression omnibus datasets.

器官移植免疫排斥

基因表达分析

Although the link between ischemia-reperfusion injury (IRI) and T cell-mediated rejection (TCMR) in kidney transplantation (KT) is well known, the mechanism remains unclear. We investigated essential

NIAID Data Ecosystem20

Results of multiple logistic regression modelling, comparing the occurrence of rejection in relation to DSA.

器官移植免疫排斥

供体特异性抗体分析

Model 1 is for DSA baseline level adjusted for age, sex, DR mismatch (0 vs. 1 or 2), previous transplant (Tx) (Yes vs. No), and baseline levels of TPA, CMV, VZV, IgA, IgG and IgM antibodies. Model 2 i

NIAID Data Ecosystem30

Lack of Association between Interleukin-10 Gene Polymorphisms and Graft Rejection Risk in Kidney Transplantation Recipients: A Meta-Analysis

器官移植免疫排斥

IL-10基因多态性

BackgroundInterleukin-10 (IL-10) is an important immunomodulatory cytokine. Several studies focused the association between IL-10 promoter gene polymorphisms and graft rejection risk in kidney transpl

Figshare2016-01-15 更新20

Enhancement of suppressive function of Ly49+ CD8+ T cells in allogeneic immunity by CD80/86-CD28 blockade

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