Expression data from sevoflurane anesthesia treated rat. Expression data from sevoflurane anesthesia treated rat

Long noncoding RNAs (lncRNAs) play important roles in brain function modulation and neurodegenerative diseases. However, whether lncRNA regulations are involved in the mechanisms of perioperative neurocognitive disorders (PNCD), especially in anesthesia related brain dysfunction, remains unknown. We explored the expression and regulation pattern profiles of lncRNAs in the hippocampus of aged rats after sevoflurane anesthesia with microarrays. Overall design: We focused on lncRNA and gene expression patterns in the hippocampus of aged rats after sevoflurane anesthesia. And we established functional annotation of differentially expressed (DE)-lncRNAs and their potential target genes, as well as lncRNA-mRNA co-expression network to reveal the role of lncRNAs in sevoflurane anesthesia related brain function modulation.