Genomic alterations underlie a pan-cancer metabolic transcriptome shift associated with hypoxic selection

ChEBI2016-03-14 更新2026-07-12 收录

癌细胞重编程

缺氧微环境适应性

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-4200 数据链接链接失效反馈

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资源简介：

Genomic alterations underlie a pan-cancer metabolic transcriptome shift associated with hypoxic selection

创建时间：

2016-03-14

Depletion of Nrf2 in pancreatic cancer cells shifts arginine metabolism into the phosphocreatine energy system. Depletion of Nrf2 in pancreatic cancer cells shifts arginine metabolism into the phosphocreatine energy system

癌细胞重编程

癌症靶向治疗

Depletion of Nrf2 leads to an increase in cellular ROS, reduced glutathione and thiols, and profound reprogramming of metabolism. Unbiased transcriptome analyses show that key enzymes of glycolysis, p

NIAID Data Ecosystem60

SCL , LMO1 and Notch1 Reprogram Thymocytes into Self-Renewing Cells

T-ALL发病机制

癌细胞重编程

The molecular determinants that render specific populations of normal cells susceptible to oncogenic reprogramming into self-renewing cancer stem cells are poorly understood. Here, we exploit T-cell a

NIAID Data Ecosystem40

The tRNA Gm18 Methyltransferase TARBP1 Promotes Hepatocellular Carcinoma Progression via Metabolic Reprogramming of Glutamine [Ribo-seq]. The tRNA Gm18 Methyltransferase TARBP1 Promotes Hepatocellular Carcinoma Progression via Metabolic Reprogramming of Glutamine [Ribo-seq]

癌细胞重编程

翻译组分析

Cancer cells rely on metabolic reprogramming to sustain the prodigious energetic requirements for rapid growth and proliferation. Glutamine metabolism is frequently dysregulated in cancers and is bein

NIAID Data Ecosystem10

Deep Quantitative Proteomics Reveals Extensive Metabolic Reprogramming and Cancer-Like Changes of Ectopic Endometriotic Stromal Cells

子宫内膜异位症蛋白质组学

癌细胞重编程

Endometriosis is a prevalent health condition in women of reproductive age characterized by ectopic growth of endometrial-like tissue in the extrauterine environment. Thorough understanding of the mol

NIAID Data Ecosystem50

Additional file 6 of m6A-dependent glycolysis enhances colorectal cancer progression

癌细胞重编程

RNA表观遗传学

Additional file 6 Table S4. m6A-seq analysis in HCT116 WT and METTL3-knockout cells.

Figshare2020-04-04 更新30