Effect of metformin on chromatin accessibility in lung cancer cells
收藏NIAID Data Ecosystem2026-03-11 收录
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资源简介：
The DNA regions whose chromatin accessibility was significantly altered by metformin were investigated in lung cancer cells by ATAC-seq. Metformin decreased chromatin accessibility in 159 regions but increased it in 124 sites. Most regions were outside of gene promoters defined as TSS ± 3kb. The most suppressed region was 4,667bp downstream of CHAC1, and the most enhanced site was 15,111bp downstream of ERRFI1. Examination of the chromatin accessibility in H1299 cells treated with or without 5mM metformin.
创建时间：
2019-11-27
