Cryo-EM structure of the GHRH-bound human GHRHR splice variant 1 complex

Cryo-EM structure of the GHRH-bound human GHRHR splice variant 1 complex Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... Authors: Cong, Z.T, Zhou, F.L, Zhang, C, Zou, X.Y, Zhang, H.B, Wang, Y.Z, Zhou, Q.T, Cai, X.Q, Liu, Q.F, Li, J, Shao, L.J, Mao, C.Y, Wang, X, Wu, J.H, Xia, T, Zhao, L.H, Jiang, H.L, Zhang, Y, Xu, H.E, Chen, X, Yang, D.H, Wang, M.W. Deposit date: 2021-08-26 Release date: 2021-10-20 Last modified: 2025-07-02 Method: ELECTRON MICROSCOPY (3.29 Å) Cite: Constitutive signal bias mediated by the human GHRHR splice variant 1. Proc.Natl.Acad.Sci.USA, 118, 2021人生长激素释放激素（GHRH）结合的生长激素释放激素受体（GHRHR）剪接变体1复合物的冷冻电镜（Cryo-EM）结构。描述：鸟苷酸结合蛋白G(I)/G(S)/G(O)亚基γ-2、鸟苷酸结合蛋白G(I)/G(S)/G(T)亚基β-1、鸟苷酸结合蛋白G(s)亚基α短亚型…… 作者：Cong Z.T、Zhou F.L、Zhang C、Zou X.Y、Zhang H.B、Wang Y.Z、Zhou Q.T、Cai X.Q、Liu Q.F、Li J、Shao L.J、Mao C.Y、Wang X、Wu J.H、Xia T、Zhao L.H、Jiang H.L、Zhang Y、Xu H.E、Chen X、Yang D.H、Wang M.W。存档日期：2021-08-26，发布日期：2021-10-20，最后修改日期：2025-07-02。方法：电子显微镜（3.29埃）。引用文献：人GHRHR剪接变体1介导的组成型信号偏倚。《美国国家科学院院刊》（Proc. Natl. Acad. Sci. USA），118卷，2021年