Exercise-induced circadian regulation

Human genes regulated in the diurnal comparison with orthologues that display circadian regulation in mouse heart and liver (Panda 2002, Storch 2002), and SCN (Panda 2002). The 608 significantly regulated (P < 0.05) hSkM genes identified in the diurnal comparison (0800 h and 2000 h) were subjected to an additional statistical filter of absolute fold change > 20% (n = 239) and linked to mouse circadianly regulated orthologues. This pathway represents the resultant 44 putative hSkM circadianly regulated genes; L, promoter for the light-responsive element; E, E-box (Clock/Bmal1 promoter). Orthologue information is denoted to the left of the gene boxes: mHrts and mLvrs, mouse orthologue was circadianly regulated as described (Storch 2002) in mouse heart or liver, respectively; mLvrp and mSCNp, mouse orthologue was diurnally regulated as described (Panda 2002) in mouse liver or SCN, respectively.

在日间与小鼠心脏、肝脏中表现出昼夜节律调控的直系同源基因（Panda 2002，Storch 2002）以及下丘脑（SCN）（Panda 2002）的比较中，共确定了608个显著调控（P < 0.05）的hSkM基因。这些基因在日间比较（0800时和2000时）中，经过绝对倍数变化大于20%（n = 239）的额外统计分析过滤，并与小鼠的昼夜节律调控直系同源基因关联。此通路代表了由此产生的44个拟hSkM昼夜节律调控基因；L，光响应元件的启动子；E，E-box（Clock/Bmal1启动子）。直系同源基因信息标注于基因框的左侧：mHrts和mLvrs，表示小鼠心脏或肝脏中的直系同源基因，其昼夜节律调控如Storch（2002）所述；mLvrp和mSCNp，表示小鼠肝脏或SCN中的直系同源基因，其日间节律调控如Panda（2002）所述。