Structure of 1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-(1-propylpiperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)urea bound to DCN1

Structure of 1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-(1-propylpiperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)urea bound to DCN1 Descriptor: Endolysin, DCN1-like protein 1 chimera, N-[(2H-1,3-benzodioxol-5-yl)methyl]-N-(1-propylpiperidin-4-yl)-N'-[3-(trifluoromethyl)phenyl]urea Authors: Guy, R.K, Schulman, B.A, Scott, D.C, Hammill, J.T. Deposit date: 2017-10-27 Release date: 2018-09-26 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.1 Å) Cite: Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation. J. Med. Chem., 61, 2018

结合DCN1的1-(苯并[d][1,3]二氧杂环戊烯-5-基甲基)-1-(1-丙基哌啶-4-基)-3-(3-(三氟甲基)苯基)脲的晶体结构。描述符：内溶素（Endolysin）、类DCN1蛋白1嵌合体、N-[(2H-1,3-苯并二氧杂环戊烯-5-基)甲基]-N-(1-丙基哌啶-4-基)-N'-[3-(三氟甲基)苯基]脲。作者：Guy, R.K.、Schulman, B.A.、Scott, D.C.、Hammill, J.T.。沉积日期：2017-10-27。发布日期：2018-09-26。最后修改日期：2023-10-04。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.1 Å）。引用文献：《哌啶基脲类化合物可化学调控Cullin Neddylation缺陷蛋白1（DCN1）介导的Cullin Neddylation过程》，《药物化学杂志》（J. Med. Chem.），第61卷，2018年。