Demographic characteristics of subjects from the PREVEND cohort that were included in and excluded from our study.

Data are expressed as mean (sd), number (%), or median [IQR] in case of skewed distributions. BMI body mass index; WHR waist-hip ratio; CV cardiovascular; SBP systolic blood pressure; DBP diastolic blood pressure; MAP mean arterial pressure; Tx therapy; LDL low density lipoprotein; eGFR estimated glomerular filtration rate; UAE urinary albumin excretion; CKD chronic kidney disease;a Defined as a clinical diagnosis of any of the following: acute myocardial infarction, (sub)acute ischemic heart disease, coronary artery bypass grafting, percutaneous transluminal coronary angioplasty, subarachnoid haemorrhage, intracerebral haemorrhage, occlusion/stenosis of the (pre)cerebral arteries, and other vascular interventions such as percutaneous transluminal angioplasty or bypass grafting of aorta/peripheral vessels.b Defined as SBP ≥ 140mmHg, DBP ≥ 90mmHg, or antihypertensive Tx.c Defined as fasting glucose > 7 mmol/L, or antidiabetic Tx. All cases were type 2 diabetes.d Defined as total cholesterol ≥ 6.21 mmol/L, or lipid lowering Tx.e Calculated using the CKD-EPI serum creatinine—serum cystatin C equation.f Defined as either eGFR 2 or UAE ≥ 30mg/24h.Smoking was self-reported “never”, “former”, “currently 20”. Tx was reported “yes” “no” or “unknown”.Two-sided p-values were calculated using t-tests, Mann-Whitney U-tests, and χ2-tests where applicable.* shows statistically significant: p-value ≤ 0.05Demographic characteristics of subjects from the PREVEND cohort that were included in and excluded from our study.