Transcriptomic analysis genes involved in the establishment and maintenance of FMDV persistent infection. Mesocricetus auratus

In FMDV persistent infection cell lines, we found that many FMDV-free cells (BHK_VEC) occupied. The BHK_VEC cells exhibited resisted to the parental FMDV, and could re-establish a persistent infection when infected with FMDV-OP, revealing a fact that host cells evolved during the persistent infection. To further explore the underlying molecular mechanism, transcriptomic analyses of BHK_VEC, BHK21 and BHK-Op cells were performed by using RNA-seq Overall design: mRNA profiles of wild-type BHK21 , FMDV persistent infection cells (BHKOp) and FMDV-free cells of persistent infection (VEC) were generated by in-depth sequencing, in triplicate, using Illumina GAIIx.