Alternate Structural Equation Models.

Alternate models were tested and are presented here. As in the manuscript, the interaction between the three gasotransmitters and their individual and combined effects on microvascular blood flow were assessed. All models were manually constructed and presented here for our three input (NO, CO and H2S) and one output (microvascular blood flow) variables. These models were then tested and assessed for suitability by χ2 Goodness of Fit and root mean square error of approximation (RMSEA). Lower χ2 values represent a better predicted model, whilst an RMSEA of below 0.06 shows a good fit. RMSEA also allows for calculation of a confidence interval (CI) around the predictive power of the model. None of these models had a more acceptable χ2 or RMSEA value and CI, thus the selection of the model presented within the manuscript. (PDF)