Integrated Transcriptome Analysis of Long Noncoding RNA and mRNA in Developing and Aging Mouse Retina

Mice serve as a widely utilized model for research of multiple retinal diseases. However, there is a dearth of comprehensive datasets encompassing the complete developmental and aging stages of the mouse retina, particularly in the elderly period, with regards to integrated lncRNA and mRNA expression profiles. Here, we collected a total of 18 retina samples from mice at 6 different stages of developing and aging (5 days, 3 weeks, 6 weeks, 10 weeks, 6 months and 15 months) for integrated lncRNA and mRNA sequencing analysis. This valuable dataset provides a comprehensive transcriptomic and epigenetic resource of mRNA and lncRNA expression profiles during natural development and aging of the retina. The findings from this study will aid in elucidating molecular mechanisms underlying various retinal diseases, including , congenital retinal dysplasia and retinal degenerative diseases.