Appendix S1 - Development of and Access to Products for Neglected Diseases

*Trouiller et al. did not include year of approval for each drug, nor the regulatory agency that made the initial approval. Using multiple sources, including IMS R&D Focus and PharmaProjects, we identified both year of approval and the regulatory agency that made the initial approval. **Trouiller et al. included fivedrugs on their 1975–1999 approvals list that were not approved during that period. First, they included pyrazinamide as a separate NCE. Our research found that this drug was first approved in 1954. However, we did find that pyrazinamide was approved as part of a combination product in 1998 (isoniazid +rifampicin + pyrazinamide + ethambutol). Second, Trouiller et al. included the atovaquone + proguanil combination as a 1975–1999 approval. However, this combination product was approved in 2000. Therefore, in our list we included it as a 2000–2008 approval. Third, Trouiller et al. included benznidazole as a drug approved between 1975 and 1999. Our research found that benznidazole was first approved in 1972. Therefore, we did not include it on our list of 1975–1999 approvals. Fourth, Trouiller et al. included nifurtimox as a drug approved between 1975 and 1999. Our research found that nifurtimox was first launched in 1967 as a drug targeting Chagas' disease. Therefore, we did not include it on our list of 1975–1999 approvals. Fifth, Trouiller et al. included pentamidine in the 1975–1999 approvals list. Our research found that pentamidine was first approved in France in 1956 as a kinetoplastid.
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