One-Pot Trifluoromethylative Functionalization of Amides: Synthesis of Trifluoromethylated Bis(indolyl)arylmethanes and Triarylmethanes
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https://figshare.com/articles/dataset/One-Pot_Trifluoromethylative_Functionalization_of_Amides_Synthesis_of_Trifluoro_methylated_Bis_indolyl_aryl_methanes_and_Triaryl_methanes/5617009
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资源简介：
Efficient and general
one-pot trifluoromethylative functionalization
of amides has been accomplished for the synthesis of various trifluoromethylated
bis(indolyl)arylmethane, utilizing trifluoromethyltrimethylsilane
and substituted indoles as nucleophiles. The developed reaction involves
the in situ generation and trapping of a trifluoromethylated
iminium ion, derived from the trifluoromethylated hemiaminal of amide,
with various substituted indoles. This method has been successfully
extended to the synthesis of diverse trifluoromethylated triarylmethanes
employing phenols as nucleophiles. Furthermore, the potential of the
method was demonstrated via the two-step synthesis of a trifluoromethylated
analog of a hypolipidemic and anti-obesity agent.
创建时间：
2017-11-20
