A Unique Combined Source of “CN” from 1,2-Dichloroethane and TMSN3 in the Copper-Catalyzed Cyanation of a C(sp3)–H Bond Adjacent to a Nitrogen Atom

A novel combined metal-free “CN” source from trimethylsilyl azide and 1,2-dichloroethane has been developed and successfully applied to copper-catalyzed oxidative cyanation of α-C–H tertiary amines for the synthesis of C1-cyanation tetrahydroisoquinoline derivatives with good to excellent yields for the first time.