Processes and phenotypes in each model species that are most enriched among the top-ranked “human disease” genes in that species.

In each species, the top-ranked genes for each human disease were identified by training a classifier trained on GenePlexusZoo’s multi-species network representation using the human disease genes and applying the trained model to predict genes in model species. The file contains a table of the Gene Ontology (GO) biological process genesets and Monarch phenotype genesets most enriched among these top-ranked genes. The columns of the file refer to the molecular network used to create the multi-species network representation (Network), the model species where predictions were made (Species), the Disease Ontology identifier of the human disease (DOID), the name of the disease (Disease Name), the number of human genes annotated to the disease (Number of Disease Genes), the subset of disease genes that have an ortholog in model species (Number of Disease Genes With Any Orthologs in Model Species), the GO or Monarch enrichment task (Task), the identifier of the process/phenotype (Term ID), the name of the process/phenotype (Term Name), the False Discovery Rate of the enrichment (FDR of Term in Model), the FDR-based enrichment rank (Rank), the number of genes in the model species annotated to that process/phenotype term (Number of Term Genes), the number of process/phenotype genes that have human orthologs (Number of Term Genes With Any Orthologs in Human), and the size of the gene overlap between the disease and the process/phenotype (Disease-Term Gene Overlap).
(TSV)