Oxidative stress generates harmful reactive oxygen species (ROS) that attack biomolecules including DNA. In living cells, there are several mechanisms for detoxifying ROS and repairing oxidatively-dam

NIAID Data Ecosystem60

RNA-seq of MCF-7 cells treated with GDC-9545 and GNE-858

乳腺癌药物机制

RNA测序分析

We measured gene expression using RNA-sequencing for MCF-7 cells treated with vehicle (DMSO), GDC-9545 or GNE-858. GNE-858 is a non-ER degrader (SERM) from the same chemical series as GDC-9545. Overal

NIAID Data Ecosystem30

Table7_A Novel DNA Repair Gene Signature for Immune Checkpoint Inhibitor-Based Therapy in Gastric Cancer.XLSX

癌症免疫治疗预测与预后

DNA修复基因

Gastric cancer is a heterogeneous group of diseases with only a fraction of patients responding to immunotherapy. The relationships between tumor DNA damage response, patient immune system and immunot

NIAID Data Ecosystem80

Additional file 10 of Antitumor activity of Z-endoxifen in aromatase inhibitor-sensitive and aromatase inhibitor-resistant estrogen receptor-positive breast cancer

乳腺癌药物机制

信号通路

Additional file 10. Ingenuity pathway analysis (IPA) indicating key molecular, cellular and signaling pathways likely impacted by Z-endoxifen treatment in the MCF7LR tumors.

Figshare2020-05-20 更新40

Resveratrol induces downregulation of DNA repair genes in MCF7 human breast cancer cells.

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