Co-structure of human glycogen synthase kinase beta with 1-(6-((2-((6-amino-5-nitropyridin-2-yl)amino)ethyl)amino)-2-(2,4-dichlorophenyl)pyridin-3-yl)-4-methylpiperazin-2-one

Co-structure of human glycogen synthase kinase beta with 1-(6-((2-((6-amino-5-nitropyridin-2-yl)amino)ethyl)amino)-2-(2,4-dichlorophenyl)pyridin-3-yl)-4-methylpiperazin-2-one Descriptor: 1-(6-((2-((6-amino-5-nitropyridin-2-yl)amino)ethyl)amino)-2-(2,4-dichlorophenyl)pyridin-3-yl)-4-methylpiperazin-2-one, Glycogen synthase kinase-3 beta, PHOSPHATE ION Authors: Bussiere, D.E, Fang, E, Shu, W. Deposit date: 2019-12-05 Release date: 2020-01-15 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.19 Å) Cite: Discovery and optimization of novel pyridines as highly potent and selective glycogen synthase kinase 3 inhibitors. Bioorg.Med.Chem.Lett., 30, 2020

人糖原合成酶激酶β（human glycogen synthase kinase beta）与1-(6-((2-((6-氨基-5-硝基吡啶-2-基)氨基)乙基)氨基)-2-(2,4-二氯苯基)吡啶-3-基)-4-甲基哌嗪-2-酮的共晶体结构
描述：1-(6-((2-((6-氨基-5-硝基吡啶-2-基)氨基)乙基)氨基)-2-(2,4-二氯苯基)吡啶-3-基)-4-甲基哌嗪-2-酮、糖原合成酶激酶3β（Glycogen synthase kinase-3 beta）、磷酸根离子（PHOSPHATE ION）
作者：Bussiere, D.E.、Fang, E.、Shu, W.
沉积日期：2019-12-05
发布日期：2020-01-15
最后修改日期：2024-11-20
实验方法：X射线衍射（X-RAY DIFFRACTION，2.19 Å）
引用文献：《新型吡啶类强效选择性糖原合成酶激酶3抑制剂的发现与优化》，发表于Bioorg.Med.Chem.Lett.，第30卷，2020年