Structure of the ligand-binding and transmembrane domains of kainate receptor GluK2 in complex with the positive allosteric modulator BPAM344 and competitive antagonist DNQX

Structure of the ligand-binding and transmembrane domains of kainate receptor GluK2 in complex with the positive allosteric modulator BPAM344 and competitive antagonist DNQX Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Yen, L.Y, Gangwar, S.P, Yelshanskaya, M.V, Sobolevsky, A.I. Deposit date: 2023-01-23 Release date: 2023-04-19 Last modified: 2024-10-30 Method: ELECTRON MICROSCOPY (3.18 Å) Cite: Positive and negative allosteric modulation of GluK2 kainate receptors by BPAM344 and antiepileptic perampanel. Cell Rep, 42, 2023

与正变构调节剂（positive allosteric modulator）BPAM344以及竞争性拮抗剂（competitive antagonist）DNQX结合的红藻氨酸受体（kainate receptor）GluK2的配体结合域与跨膜域结构
描述物：(2S)-3-(十六酰氧基)-2-[(9Z)-十八碳-9-烯酰氧基]丙基 2-(三甲基铵基)乙基磷酸酯、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖，……
作者：Yen, L.Y、Gangwar, S.P、Yelshanskaya, M.V、Sobolevsky, A.I.
提交日期：2023-01-23
发布日期：2023-04-19
最后修改日期：2024-10-30
实验方法：电子显微镜（3.18 Å）
引用文献：BPAM344与抗癫痫药物吡仑帕奈对GluK2红藻氨酸受体的正负变构调控作用。Cell Rep，42卷，2023年