Replication Data for: Meta-analytic connectivity modelling of functional magnetic resonance imaging studies in autism spectrum disorders

The current meta-analysis investigated activation differences between ASD and neurotypical controls irrespective of task type. Activation likelihood estimation meta-analyses were performed to examine consistent hypo-activated and/or hyper-activated regions for all tasks combined, and for social and non-social tasks separately; meta-analytic connectivity modelling and behavioral/paradigm analyses were performed to examine co-activated regions and associated behaviors. One hundred studies (mean age range=18-41 years) were included. The ASD group showed significant (p<0.05) hypo-activation in one cluster around the left amygdala (-22, 0, -18, volume=1224 mm3, maximum ALE=0.023), and this cluster co-activated with two other clusters around the right cerebellum (42, -56, -22, volume=2560mm3, maximum ALE=0.046) Lobule VI/Crus I and the left fusiform gyrus (BA47) (-42, -46, -18, volume=1616, maximum ALE-0.046) and left cerebellum (-42, -58, -20, volume=1616mm3, maximum ALE=0.033) Lobule VI/Crus I. While the left amygdala was associated with negative emotion (specifically fear) (z=3.047), the left fusiform gyrus/cerebellum Lobule VI/Crus I cluster was associated with language semantics (z=3.724) and action observation (z=3.077). These findings highlight the left amygdala as a region consistently hypo-activated in ASD and suggest the potential involvement of fusiform gyrus and cerebellum in social cognition in ASD.