Additional file 1 of Longitudinal analysis of cell-free mutated KRAS and CA 19–9 predicts survival following curative resection of pancreatic cancer

Additional file 1: Supplemental Figure 1. Univariate survival analyses for established clinicopathologic variables. A, B) Kaplan-Meier estimates of RFS (A) and OS (B) for PDAC patients stratified in two groups: patients with R1 vs. R0 resection. (C, D) Kaplan-Meier estimates of RFS (C) and OS (D) for PDAC patients stratified by postoperative CA 19–9 levels: elevated (> 36 U/mL) versus normal (≤ 36 U/mL). (E, F) Kaplan-Meier estimates of RFS (E) and OS (F) for resected PDAC patients with/without adjuvant chemotherapy. OS, overall survival; RFS, recurrence-free survival; PDAC, pancreatic ductal adenocarcinoma. Univariate analyses were performed using the log-rank test. Supplemental Figure 2. Association of cfKRASmut with survival endpoints and clinicopathologic variables. (A, B) Kaplan-Meier estimates of RFS (A) and OS (B) for patients following curative resection of PDAC with versus without cfKRASmut cut-off level of > 0.5% variant allele frequency (VAF) at any time point during study period. (C, D, E) cfKRASmut (C), total cell-free DNA (D) and CA 19–9 levels (E) in untreated resected PDAC patients were compared to resection margin. OS, overall survival; RFS, recurrence-free survival; PDAC, pancreatic ductal adenocarcinoma