Fine-mapping results for the EstBB-UKBB NMR metabolic trait meta-analysis

Files contained in this repository: UKBB_EUR_fine_mapping_with_meta_EUR_lead_variants.parquet - main table with all fine mapped credible sets. UKBB_EUR_fine_mapping_missense_snps.tsv.gz - missense variants among the credible set variants (indentified by Ensembl VEP). UKBB_EUR_fine_mapping_splicing_predictions.tsv.gz - SpliceAI and AlphaGenome predictions for all credible set variants. UKBB_EUR_annotated_high_PIP_variants.tsv.gz - filtered list of PIP > 0.8 variants and credible sets to which they belong, annotated with missense and splicing predictions. Column names of for the fine mapping results (UKBB_EUR_fine_mapping_with_meta_EUR_lead_variants.parquet) molecular_trait_id - name of metabolic trait region - region in which the credible set variants are situated variant - variant in credible set chromosome - chromosome position - position (GRCh38) ref - reference allele alt - alternative allele maf - minor allele frequency in UKBB_EUR cohort cs_id - credible set ID cs_index - credible set index alpha1 - point estimate of causal effect for signal 1 alpha2 - point estimate of causal effect for signal 2 alpha3 - point estimate of causal effect for signal 3 alpha4 - point estimate of causal effect for signal 4 alpha5 - point estimate of causal effect for signal 5 alpha6 - point estimate of causal effect for signal 6 alpha7 - point estimate of causal effect for signal 7 alpha8 - point estimate of causal effect for signal 8 alpha9 - point estimate of causal effect for signal 9 alpha10 - point estimate of causal effect for signal 10 pip - posterior inclusion probability z - Z-score