Transcription profile of an azole resistant mutant of Mycobacterium truberculosis. Mycobacterium tuberculosis

We used DNA microarrays to detect differentially expresses genes in a spontaneous mutant of Mycobacterium tuberculosis H37Rv resistant to azoles. We identified three adjacent upregulated genes encoding a transcription regulatory protein and two membrane proteins belonging to the family of RND efflux transporters. Overall design: Hybridization were performed using RNA extracted from three different biological samples coming from cultures grown in mid-exponential phase.