HVN Los aMiGos Metadata Record - Is LactOSe tolerance impacted by repeated exposure to A2 beta-casein MIlk, with effects on Gut COmfort Symptoms

This metadata record and it's attached files make statements about the kinds of data collected as part of this research, and set out policies for governance of that data, now and in the future.Description: Many people report digestive problems with dairy products. This dairy intolerance may sometimes be caused by lactose intolerance, but not all people reporting intolerance have confirmed lactose intolerance. Rather, some forms of dairy intolerance may be caused or exacerbated by the protein in milk which manifests as inflammation of the small intestine. Conventional milk contains the A1 version of bovine beta-casein protein. A1 beta-casein may cause intolerance type symptoms in some consumers, resulting in small intestinal inflammation that may also contribute to lactose intolerance. It is proposed that these effects are absent or reduced when dairy products free of this variant are consumed. The A2 version of beta-casein is broken down differently, and may not cause intolerance symptoms in consumers who are sensitive to the A1 beta-casein protein. However, the impacts of variation in beta-casein and intestinal inflammation on lactose malabsorption have not yet been investigated in humans. Due to the possible exacerbation of lactose malabsorption by intestinal inflammation, this study aims to understand whether tolerance to lactose is impacted by repeated exposure to variants of beta-casein.本元数据记录及其附带文件说明了本研究收集的各类数据范畴，并制定了该数据当前及未来的治理政策。研究说明：不少人群称食用乳制品后会出现消化不适症状。这类乳制品不耐受有时可由乳糖不耐受引发，但并非所有报告不耐受的人群均经确诊为乳糖不耐受。实际上，部分乳制品不耐受或由乳蛋白诱发或加重，表现为小肠炎症。常规牛乳含有A1型牛β-酪蛋白（bovine beta-casein），部分消费者摄入A1 β-酪蛋白后可能出现不耐受类症状，引发小肠炎症，该炎症还可能进一步加重乳糖不耐受。有研究提出，若食用不含该变体的乳制品，则不会出现或可减轻此类不良反应。β-酪蛋白（beta-casein）的A2变体分解方式不同，对A1 β-酪蛋白敏感的消费者而言，摄入A2变体或不会引发不耐受症状。然而，目前尚未针对人类开展β-酪蛋白变体与肠道炎症对乳糖吸收不良的影响相关研究。鉴于肠道炎症可能加重乳糖吸收不良，本研究旨在探究反复摄入β-酪蛋白变体是否会对乳糖耐受性产生影响。