Memory like NK cells display stem cell like properties after Zika virus infection

In this study, we show that CD27+ memory like NK cells generated following Zika virus infection exhibited stem-like features viz., self-renewal pathway, differentiation into effector cells and longer telomeres, and greater therapeutic potential than CD27- and naive CD27+ NK cells when adoptively transferred to Zika virus infected mice. In addition, epigenetic landscape of CD27+ memory like NK is markedly different compared to CD27- NK cells. ATACseq of naive, CD27+ (stem cell like memory) and CD27- (nonmemory) NK cells in triplicates using Illumina HiseqX.