Crystal Structure of the Human vaccinia-related kinase 1 (VRK1) bound to an N-propynyl-N-isopentyl-dihydropteridin inhibitor

Crystal Structure of the Human vaccinia-related kinase 1 (VRK1) bound to an N-propynyl-N-isopentyl-dihydropteridin inhibitor Descriptor: (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-8-(3-methylbutyl)-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5H)-one, (7S)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-8-(3-methylbutyl)-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5H)-one, ACETATE ION, ... Authors: Counago, R.M, dos Reis, C.V, de Souza, G.P, Azevedo, A, Guimaraes, C, Mascarello, A, Gama, F, Ferreira, M, Massirer, K.B, Arruda, P, Edwards, A.M, Elkins, J.M, Structural Genomics Consortium (SGC) Deposit date: 2018-03-09 Release date: 2018-04-04 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal Structure of the Human Vaccinia-Related Kinase 1 (VRK1) bound to a N-propynyl-N-isopentil-dihydropteridine inhibitor To Be Published

人痘病毒相关激酶1（Human vaccinia-related kinase 1, VRK1）结合N-丙炔基-N-异戊基二氢蝶啶类抑制剂的晶体结构。配体描述：(7R)-2-[(3,5-二氟-4-羟基苯基)氨基]-7-甲基-8-(3-甲基丁基)-5-(丙-2-炔-1-基)-7,8-二氢蝶啶-6(5H)-酮、(7S)-2-[(3,5-二氟-4-羟基苯基)氨基]-7-甲基-8-(3-甲基丁基)-5-(丙-2-炔-1-基)-7,8-二氢蝶啶-6(5H)-酮、乙酸根离子（ACETATE ION）。作者：Counago, R.M.、dos Reis, C.V.、de Souza, G.P.、Azevedo, A.、Guimaraes, C.、Mascarello, A.、Gama, F.、Ferreira, M.、Massirer, K.B.、Arruda, P.、Edwards, A.M.、Elkins, J.M.，结构基因组学联盟（Structural Genomics Consortium, SGC）。提交日期：2018-03-09。发布日期：2018-04-04。最后修改日期：2023-10-04。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2 Å（埃）。引用信息：《结合N-丙炔基-N-异戊基二氢蝶啶类抑制剂的人痘病毒相关激酶1（VRK1）晶体结构》，待发表。