Asymmetric Glycolate Aldol Reactions Using Cinchonium Phase-Transfer Catalysts
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https://figshare.com/articles/dataset/Asymmetric_Glycolate_Aldol_Reactions_Using_Cinchonium_Phase_Transfer_Catalysts/3270295
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资源简介：
Cinchona phase-transfer catalysts (PTC) were developed for glycolate aldol reactions to give differentially protected 1,2-diol products. Silyl
enol ether 9 reacted to generate benzhydryl-protected products. O-Allyl trifluorobenzyl cinchonium hydrofluoride CN-4 (20 mol %) catalyzed
the addition of 9 to benzaldehyde to give 8 as a single syn-product in 76% yield and 80% ee. Recrystallization enriched the product to 95%
ee, and a Baeyer−Villiger reaction transformed the product into useful ester intermediates.
创建时间：
2016-05-05
