Transcription profiling of Smarce1- AID mESCs , cultured the cells with IAA treatment from 0min to 7 days.

To evaluate the effects of degradation of SMARCE1 upon gene expression, we performed RNA-sequencing (RNA-seq) of cultures of two Smarce1-AID mESCs. We found that transcription of the core pluripotency regulatory network was disrupted starting from 240min and there is an accumulation till day 7 . We performed RNA-seq in two Smarce1-AID clones mESCs in time course manner.