The Heritage family study - skeletal muscle gene expression

Gene expression profiles generated from skeletal muscle biopsies taken from participants of the HERITAGE family study. Participants completed an endurance training regime in which a skeletal muscle biopsy was taken prior to the start and after the final session of the program. Biopsies were used to generate Affymetrix gene expression microarrays. The experimental design and exercise training protocol of the HERITAGE Family Study have been described previously (Bouchard et al., 1995). Participants were sedentary at baseline and normotensive. Each participant exercised three times per week for 20 weeks on cycle ergometers controlled by direct heart rate (HR) monitoring. Muscle biopsies of vastus lateralis were obtained at baseline and post-training.