CREBBP bromodomain in complex with Cpd19 (3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-N-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide)

CREBBP bromodomain in complex with Cpd19 (3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-N-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide) Descriptor: 3-[7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl]-N-methyl-1-(oxan-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide, CREB-binding protein Authors: Murray, J.M. Deposit date: 2017-05-30 Release date: 2018-02-21 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.41 Å) Cite: A Unique Approach to Design Potent and Selective Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) Inhibitors. J. Med. Chem., 60, 2017

CREB结合蛋白溴结构域（CREBBP bromodomain）与化合物Cpd19【3-(7-(二氟甲基)-6-(1-甲基-1H-吡唑-4-基)-3,4-二氢喹啉-1(2H)-基)-N-甲基-1-(四氢-2H-吡喃-4-基)-1,4,6,7-四氢-5H-吡唑并[4,3-c]吡啶-5-甲酰胺】形成的复合物，其描述符为3-[7-(二氟甲基)-6-(1-甲基-1H-吡唑-4-基)-3,4-二氢喹啉-1(2H)-基]-N-甲基-1-(四氢-2H-吡喃-4-基)-1,4,6,7-四氢-5H-吡唑并[4,3-c]吡啶-5-甲酰胺，相关蛋白为环腺苷单磷酸应答元件结合蛋白结合蛋白（CREB-binding protein, CBP）。作者：Murray, J.M.，存入日期：2017年5月30日，发布日期：2018年2月21日，最后修改日期：2023年10月4日，实验方法为X射线衍射（分辨率1.41埃），引用文献为《设计强效且选择性的环腺苷单磷酸应答元件结合蛋白结合蛋白（CBP）抑制剂的独特策略》，刊载于《药物化学杂志》（J. Med. Chem.）第60卷，2017年。