Ternary complex crystal structure of DNA polymerase Beta with 5-hydroxymethyl-dC (5-hmC) at the templating position
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Ternary complex crystal structure of DNA polymerase Beta with 5-hydroxymethyl-dC (5-hmC) at the templating position Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]guanosine, DNA (5'-D(*CP*CP*GP*AP*CP*(5HC)P*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), ... Authors: Batra, V.K, Wilson, S.H. Deposit date: 2018-11-14 Release date: 2019-03-27 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Molecular basis for the faithful replication of 5-methylcytosine and its oxidized forms by DNA polymerase beta. J.Biol.Chem., 294, 2019
模板位点携带5-羟甲基脱氧胞苷(5-hydroxymethyl-dC,5-hmC)的DNA聚合酶β(DNA polymerase Beta)三元复合物晶体结构
组分:2'-脱氧-5'-O-[(R)-羟基{[(S)-羟基(膦酰氧基)膦酰基]甲基}膦酰基]鸟苷、DNA(5'-D(*CP*CP*GP*AP*CP*(5HC)P*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3')、DNA(5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3')……
作者:Batra, V.K、Wilson, S.H.
提交日期:2018-11-14
发布日期:2019-03-27
最后修改日期:2023-10-11
实验方法:X射线衍射(X-RAY DIFFRACTION,2.6 Å)
引用文献:《DNA聚合酶β忠实复制5-甲基胞嘧啶及其氧化形式的分子基础》,《生物化学杂志》(J.Biol.Chem.),2019年,第294卷
创建时间:
2018-11-14



