LSD1-CoREST in complex with T14, long soaking

LSD1-CoREST in complex with T14, long soaking Descriptor: Lysine-specific histone demethylase 1A, REST corepressor 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (2R,3S,4S)-5-[(4aS)-7,8-dimethyl-5-(3-{4-[(5-methyl-1,3,4-thiadiazol-2-yl)carbamoyl]phenyl}propanoyl)-2,4-dioxo-3,4,4a,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate (non-preferred name) Authors: Caroli, J, Mattevi, A. Deposit date: 2023-01-08 Release date: 2024-08-07 Last modified: 2025-08-20 Method: X-RAY DIFFRACTION (2.89 Å) Cite: Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance. Nat Commun, 16, 2025与T14结合的LSD1-CoREST复合物，长时浸泡实验 描述符：赖氨酸特异性组蛋白去甲基化酶1A（Lysine-specific histone demethylase 1A）、REST共阻遏因子1（REST corepressor 1）、[(2R,3S,4R,5R)-5-(6-氨基-9H-嘌呤-9-基)-3,4-二羟基四氢呋喃-2-基]甲基 (2R,3S,4S)-5-[(4aS)-7,8-二甲基-5-(3-{4-[(5-甲基-1,3,4-噻二唑-2-基)氨基甲酰基]苯基}丙酰基)-2,4-二氧代-3,4,4a,5-四氢苯并[g]蝶啶-10(2H)-基]-2,3,4-三羟基戊基二氢二磷酸（非推荐命名） 作者：Caroli J、Mattevi A 存档日期：2023-01-08 发布日期：2024-08-07 最后修改日期：2025-08-20 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.89埃（Å） 引用文献：《共价加合物与Grob碎裂揭示LSD1去甲基化酶特异性抑制剂的作用机制与耐药性》，《自然通讯》（Nat Commun），第16卷，2025年