Divergent recruitment of developmentally defined neuronal ensembles supports memory dynamics

Memories are dynamic constructs whose properties change with time and experience. The biological mechanisms underpinning these dynamics remain elusive, particularly concerning how shifts in the composition of memory-encoding neuronal ensembles influence a memory properties' evolution over time. By leveraging a developmental approach to target distinct subpopulations of principal neurons, we show that memory encoding results in the concurrent establishment of multiple memory traces in the mouse hippocampus. Two of these traces are instantiated in subpopulations of early- and late-born neurons and follow distinct reactivation trajectories post-encoding. Notably, the divergent recruitment of these subpopulations underpins memory ensembles’ gradual reorganization, and modulates memory persistence and plasticity across multiple learning episodes. Thus, our findings reveal profound and intricate relationships between ensemble dynamics and memories’ progression over time., , , # Divergent Recruitment of Developmentally-Defined Neuronal Ensembles Supports Memory Dynamics

[https://doi.org/10.5061/dryad.rr4xgxdfk](https://doi.org/10.5061/dryad.rr4xgxdfk)

This dataset contains behavioural, histological, and calcium activity of a study aimed at dissecting the role of Early Born Neurons (EBNs) and Late Born Neurons (LBNs) from hippocampal area CA3 to memory encoding, processing, and recall.

## Description of the data and file structure

The data are tabulated in Excel files, each tab refers to a different variable measured and/or a different experiment.
Within the table, a brief legend indicates the nature of the data presented. The matlab files report binary traces from calcium imaging experiments. Each file identifier corresponds to an individual animal from the experiment. The file contains two numerical matrices: one with dF/F of every co-recorded neuron alogned throughput the experiments, and one indicating the boundaries (frames numbers) of each individual...