Cd2ap

This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. The mouse genome contains at least two pseudogenes located on chromosomes 9 and 17. [provided by RefSeq, Jul 2008]

本基因编码一种调节肌动蛋白细胞骨架的支架分子。该蛋白质通过多个肌动蛋白结合位点、SH3结构域和富含脯氨酸的区域，这些区域含有SH3结构域的结合位点，直接与丝状肌动蛋白及多种细胞膜蛋白相互作用。细胞质蛋白定位于膜皱褶、脂筏以及细胞的尖端。它在受体内吞作用和细胞分裂过程中发生的动态肌动蛋白重塑和膜转运中发挥作用。小鼠基因组中至少包含两个假基因，分别位于第9号和第17号染色体上。[由RefSeq提供，2008年7月]