Differentially expressed genes of C2C12 cells influenced by murine pancreatic cancer derived exosomes. Differentially expressed genes of C2C12 cells influenced by murine pancreatic cancer derived exosomes

Mice pancreatic cancer derived exosomes(KPC-exosomes) could induce skeletal muscle cells(C2C12) insulin resistance and exosomal microRNAs (miRNAs) may exert an important effect (Sci Rep. 2017;7(1):5384). The data set GSE95741 provided the differentially expressed micro RNAs. In this work, we aim to detect the differentially expressed genes and explore the intrinsic link. Overall design: C2C12 cells cultured in 25cm2 culture-flasks were treated by KPC-exo (4ug) for 24h. The C2C12 cells treated by MPDC-exo (exosomes secreted by murine pancreatic ductal epithelial cells) were used as control.